Our understanding of AAV is increasing

AAV (ANCA-associated vasculitis) is a group of progressive, rare, severe autoimmune diseases1,2

AAV can affect blood vessels in different parts of the body resulting in damage to vital organs such as the lungs, kidneys, nervous system, gastrointestinal system, skin, eyes, and heart.2

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Recent updates

Rare Revolution Magazine – May edition

The latest edition of Rare Revolution Magazine is dedicated exclusively to ANCA-associated vasculitis. Rare Revolution is a digital magazine giving a voice to patients affected by RARE conditions and the charities that represent and support them – you can view the May edition here.

ECRD 2020

SEE ME. HEAR ME. Support for anyone living with, or affected by, ANCA-associated vasculitis (AAV).


WCN 2020

Real world clinical outcomes in ANCA associated vasculitis (AAV) – unmet needs in achieving and sustaining remission and avoiding cumulative organ damage.

Abstract Poster

Investigate AAV

Join the Rare Disease Investigation Team and put your expertise to the test in our interactive challenge. You’ll find it’s fully compatible with most desktop and mobile/tablet browsers (not for use on older versions of Internet Explorer or on Microsoft Edge).

Complete the challenge

Patient videos

Patient videos - view stories from Catherine, Jeremy, John & Susan and Shanali on the patient experience page.



Adverse events and infections as major concerns with remission induction therapy of ANCA-associated vasculitis.


High burden of disease for AAV patients in Germany - a claims study.


Renal damage in ANCA-associated vasculitis in incident and relapsing patients.

Slide deck

EULAR 2019

Economic burden of ANCA-associated vasculitis in Germany - a claims data study.


Adverse events due to high-dose glucocorticoids - lessons from ANCA-associated vasculitis and other inflammatory diseases.


Severity and response to induction therapy in new and relapsing ANCA-associated vasculitis patients - real world practice data.


Introduction to AAV

AAV is a rare, severe small vessel vasculitis that affects multiple organs and has a high acute mortality risk1

Disease mechanism

The interaction between the activated alternative complement pathway, neutrophils and C5a is at the heart of vasculitic damage in AAV2

Current therapies

Treatment has improved but treatment-related complications remain common3

Patient experience

AAV is an emotional journey from the patient's perspective4-6

Investigate AAV

Take the interactive challenge to assess your understanding of AAV. Fully interactive version available on desktop only

References & footnotes