Our understanding of AAV is increasing

AAV (ANCA-associated vasculitis) is a group of progressive, rare, severe autoimmune diseases1,2

AAV can affect blood vessels in different parts of the body resulting in damage to vital organs such as the lungs, kidneys, nervous system, gastrointestinal system, skin, eyes, and heart.2

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Recent updates

Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Achieving and Sustaining Remission while Reducing Organ Damage

Interviews with Three Key Opinion Leaders

European Medical Journal article

ASN 2019

Glucocorticoids for Remission Induction in Incident ANCA-Associated Vasculitis (AAV) Patients in Real-World Practice: High Exposure and Temporal Relationship to Adverse Events

Abstract Poster

Maintenance Treatment in ANCA-Associated Vasculitis (AAV): Definition, Clinical Outcomes, and Significant Burden of Disease in Real-World Clinical Practice

Abstract Poster

AAV Mechanism of Disease

See how the interaction between neutrophils and the alternative complement system are at the heart of the vasculitic process in AAV

More information

Patient videos

Patient videos - view stories from Catherine, Jeremy, John & Susan and Shanali on the patient experience page

Vasculitis videos patient catherine
Vasculitis videos patient john
Vasculitis videos patient jeremy
Vasculitis videos patient shanali

Investigate AAV

Join the Rare Disease Investigation Team and put your expertise to the test in our interactive challenge. You’ll find it’s fully compatible with most desktop and mobile/tablet browsers (not for use on older versions of Internet Explorer or on Microsoft Edge)

Complete the challenge

Investigate vasculitis challenge infographic
Investigate vasculitis challenge infographic
See Me Hear Me banner vasculitis patient website

Introduction to AAV

AAV is a rare, severe small vessel vasculitis that affects multiple organs and has a high acute mortality risk

Vasculitis artwork pathway torso

Disease mechanism

The interaction between the activated alternative complement pathway, neutrophils and C5a is at the heart of vasculitic damage in AAV

Vasculitis artwork pathophysiology

Current therapies

Treatment has improved but treatment-related complications remain common

Vasculitis artwork kidneys

Patient experience

AAV is an emotional journey from the patient's perspective

Vasculitis artwork patient portrait

Investigate AAV

Take the interactive challenge to assess your understanding of AAV. Fully interactive version available on desktop only

Vasculitis artwork lungs